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The US Food and Drug Administration (FDA) has cleared andexanet alfa (Andexxa) as a reversal agent for the anticoagulant effects of the two most commonly used factor Xa inhibitors in patients with life-threatening or uncontrolled bleeding, manufacturer Portola Pharmaceuticals The antidote is indicated for use in patients who bleed while taking either rivaroxaban (Xarelto; Bayer/Janssen) or apixaban (Eliquis; Bristol-Myers Squibb), but the indication does not cover the other direct factor Xa inhibitors edoxaban (Savaysa; Daiichi Sankyo) and betrixaban (Bevyxxa)—which was Jean Connors, MD (Brigham and Women’s Hospital, Boston, MA), told TCTMD the availability of andexanet alfa is critical because other strategies for reversing bleeding in patients treated with the factor Xa inhibitors are only partially effective.There was no specific reversal agent for this class of drugs until now.

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It should be noted that the trophy label is often perceived as objectifying the partner, with or without the partner's implicit consent.

Additionally, it is common to see monogamous relationships widely in more modern societies as there are more women in the marriage market and polygamy is illegal throughout most of Europe and the United States.

In extreme cases, a person who marries into an extremely wealthy family can be labelled a gold digger , especially in cases where the wealthy partner is of extreme age or poor health; this term often describes women but can be applied to either gender.

Using the same pathogen-stress model we see a lower prevalence of disease in these economically developed areas, and therefore a reduced stress on reproduction for survival.

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Its use requires: an astute judgment, and striking a sensitive balance between when to stop Andexanate alfa and to restart OAC (Rivaroxaban and Apixaban).

My approach is: to identify the precise cause of bleed and to fix it as rapidly as possible (many patients have an identifiable cause of such bleeds).

An older male is more likely to have more resources to provide to the family.

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